講述生活一團糟的高中生劉慧靜與因手術失誤的陰影選擇逃避為生物教師的洪智弘間好感剛萌芽卻被嫉妒慧靜的同學陳瑞雨誣衊兩人有超乎師生的不當關係。13年後慧靜與瑞雨成為國日醫院的神經外科主治醫生，而智弘則成為神經外科的醫學教授，三人與鄭允道醫生及醫療團隊一起克服與面對各種醫學難題與醫療個案。允道在與慧靜共事的過程中對她暗生情愫。全劇主軸通過愛情展現劇中人物變化與成長的故事，探討生命的意義，而劇中人物的愛恨糾葛與調查慧靜奶奶姜末順的死亡真相也是看點之一。本劇通過主角的視角探討人性與社會的現實面。

Yoo Hye-jung was a wayward girl in high school with a prickly, gangster personality. Due to her many childhood scars, Hye-jung keeps her heart closed towards other people. However, she changes after meeting her mentor Hong Ji-hong, who plays a key role in transforming her life from a “hopeless” delinquent to a compassionate doctor. They part ways subsequently but meet again after 13 years, when Yoo Hye-jung becomes a doctor.